Dr Pham Thanh Duy
Pham Thanh Duy
Head of OUCRU Molecular Epidemiology Group
Dr Duy Pham is a Wellcome Trust Fellow and Head of Molecular Epidemiology Group at Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Vietnam. Dr Pham is a molecular biologist and has expertise in genomics and molecular epidemiology of bacterial infections. His research integrates advanced molecular biology and genomics with epidemiological surveillance and clinical study to address drug-resistant bacterial infections in Vietnam and across Asia. He has been working on typhoid fever (S. Typhi and S. Paratyphi A), and diarrheal diseases (i.e. diarrhea-causing E. coli, Shigella spp) since 2008, and have recently expanded his research interests in bloodstream infections (i.e. E. coli, K. pneumoniae), and nosocomial infections (i.e. A. baumanii, K. pneumoniae). His research aims to provide better understanding of the evolution, transmission dynamics, and clinical impact of drug-resistant bacteria in low- and middle-income settings for guiding public health interventions and improving clinical practices.
His current project focuses on combining genomics, RNA sequencing and evolutionary experiments with clinical study to investigate the emergence and impact of azithromycin-resistant Salmonella Typhi, the causative agent of typhoid fever. Additional project includes understanding the impact of antimicrobial exposure on human gut microbiome, horizontal gene transfer, and the development of drug resistance. He is also working on studying the ecology and evolution of hypervirulence and antimicrobial resistance in Klebsiella pneumoniae.
Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei
Chung The H. et al, (2019), Nature Communications, 10
Azithromycin Resistance in Shigella spp. in Southeast Asia
Darton TC. et al, (2018), Antimicrobial Agents and Chemotherapy, 62
Assessing gut microbiota perturbations during the early phase of infectious diarrhea in Vietnamese children
The HC. et al, (2018), Gut Microbes, 9, 38 - 54
Phenotypic and genotypic characteristics of ESBL and AmpC producing organisms associated with bacteraemia in Ho Chi Minh City, Vietnam
Lan NPH. et al, (2017), Antimicrobial Resistance & Infection Control, 6
An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever
Tran Vu Thieu N. et al, (2017), Journal of Infection, 75, 104 - 114