Dr Sophie Uyoga
Contact information
Research groups
Sophie Uyoga
Research scientist
Sophie trained as a biochemist in Kenya then specialized in Immunology and later obtained a PhD from the University of Heidelberg. Sophie has great interest in understanding how human genetics influences susceptibility to severe malaria. Her work focuses on red blood cell genetic polymorphisms namely hemoglobin S, alpha thalassemia, glucose-6-phosphate dehydrogenase deficiency and blood group antigens and also explores the effect of co-inheritance on protection afforded against severe malaria and other infectious diseases.
A Mid-Career research fellowship awarded by the Initiative to Develop African Research Leaders (IDeAL) has enabled Sophie to pursue another area of interest. She will be investigating the mechanisms behind the development and treatment of severe anemia with focus on the quality of donor blood on recovery from severe anemia and survival post-transfusion. She envisions that the study findings will inform future strategies to ensure efficient provision of services by blood transfusion services and policy makers in Africa.
Recent publications
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Blood transfusion for children in sub-Saharan Africa: 200 years on.
Uyoga S. et al, (2023), The Lancet. Child & adolescent health, 7, 525 - 526
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Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial
Taylor WR. et al, (2023), The Lancet Infectious Diseases, 23, 471 - 483
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Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial
Olupot-Olupot P. et al, (2023)
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Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial
Olupot-Olupot P. et al, (2023)
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High false discovery rate of the Architect anti-HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing.
Lucey O. et al, (2022), Vox sanguinis