Dr Sophie Uyoga
Contact information
Research groups
Sophie Uyoga
Research scientist
Sophie trained as a biochemist in Kenya then specialized in Immunology and later obtained a PhD from the University of Heidelberg. Sophie has great interest in understanding how human genetics influences susceptibility to severe malaria. Her work focuses on red blood cell genetic polymorphisms namely hemoglobin S, alpha thalassemia, glucose-6-phosphate dehydrogenase deficiency and blood group antigens and also explores the effect of co-inheritance on protection afforded against severe malaria and other infectious diseases.
A Mid-Career research fellowship awarded by the Initiative to Develop African Research Leaders (IDeAL) has enabled Sophie to pursue another area of interest. She will be investigating the mechanisms behind the development and treatment of severe anemia with focus on the quality of donor blood on recovery from severe anemia and survival post-transfusion. She envisions that the study findings will inform future strategies to ensure efficient provision of services by blood transfusion services and policy makers in Africa.
Recent publications
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A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa
Olupot‐Olupot P. et al, (2022), American Journal of Hematology, 97, 527 - 536
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Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial
George EC. et al, (2022), The Lancet Global Health, 10, e360 - e368
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Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations.
Nyagwange J. et al, (2021), Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 146
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Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data
Connon R. et al, (2021), BMC Public Health, 21
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COVID-19 transmission dynamics underlying epidemic waves in Kenya.
Brand SPC. et al, (2021), Science (New York, N.Y.), 374, 989 - 994