Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

OUCRU’s Director, Professor Guy Thwaites, has recently contributed to an analysis of antibacterial agents in preclinical and clinical development by the World Health Organisation (WHO), as part of the WHO advisory group on research and development of antibacterial treatments.

Various coloured pills

The advisory group met virtually on 29 and 30 November 2021 to discuss and evaluate pipelines of antibacterial candidates in different stages of development around the globe. The resulting report – titled “2021 Antibacterial agents in clinical development and preclinical: an overview and analysis” – covers 77 antibacterial agents in clinical development, 45 of which are traditional (direct-acting small molecules) agents and 32 are non-traditional agents.

The report shows that the development of new antibacterial treatments is insufficient to tackle the increasing threat of antibiotic resistance. The number of new antibiotics in the preclinical stage has remained relatively constant over the last 3 years. However, in the clinical stage, there were only 27 new products against priority pathogens in 2021, compared to 31 products in 2017. Amongst those, only 6 fulfill at least one of WHO’s criteria for innovation. This is due to barriers such as the lengthy approval pathway, high cost, low success rates, and impact of the COVID-19 pandemic.

The 2021 analysis suggests that the issue demands urgent and concerted efforts from both governments and the private sector. They need to work together to accelerate the innovation of antibiotics, especially those that can make an impact in low-resource settings where antimicrobial resistance is most visible. There should also be collaboration across countries to create sustainable solutions, enhance research and development, as well as establish a viable ecosystem for antibiotics.

Visit Professor Guy Thwaites research profile

The full story is available on the OUCRU website

Similar stories

World Hepatitis Day: OUCRU research seeks to lower cost of treatment and improve access to care for patients with hepatitis C

Today is World Hepatitis Day. OUCRU and hospitals in Ho Chi Minh City and Hanoi have been collaborating on hepatitis C clinical trials since 2018. Our research is centred around predictive factors for selecting persons who could be successfully treated with shorter durations of antiviral therapy. OUCRU’s social science and public engagement teams are currently working with underrepresented groups to create community-led strategies to link care and treatment for populations at risk for viral hepatitis. Our aim is to have a more significant impact on the treatment strategy and access to care for patients with hepatitis C in Vietnam and worldwide in the future.

Dengue Research Article Awarded The 2021 – 2022 Alexandre Yersin Prize for Outstanding Publications

OUCRU research article titled ‘Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes’ was recently awarded the 2021-2022 Alexandre Yersin Prize for Outstanding Publications.

OUCRU SPEAR Digital Diaries

Healthcare workers and community members in Indonesia, Nepal and Vietnam have been documenting their personal experiences of Covid-19. They have each made their own ‘digital diary’, using a range of creative tools and with technical support from the project team. These diaries form part of the SPEAR project: exploring the experiences and impacts of COVID-19 for healthcare workers and vulnerable communities.

Clinical trials for a malaria vaccine start in Mali and Indonesia

Sanaria Inc. announced that two new Phase 2 trials of its pioneering malaria vaccines have started. The first is in 6- to 10-year-old children living in Bancoumana, Mali, a malarious region of West Africa. The second is in Indonesian soldiers based in Sumatra, Indonesia. The soldiers will be deploying for six to nine months this coming August to an intensely malarious district in eastern Indonesia.

Congratulations to our new Associate Professors

Our heartfelt congratulations to Melissa Kapulu, Francis Ndungu and Emelda Okiro from KWTRP, and to Hoa Thi Ngo and Sophie Yacoub from OUCRU who have been awarded Associate Professorships

First-of-its-kind study found equine antitoxin is safe and effective for the treatment of tetanus in adults

A first-of-its kind randomised controlled trial compared two different antitoxin treatments for tetanus. A comparison of human and equine intramuscular antitoxin in adults found that intramuscular equine antitoxin is safe and effective for treating tetanus in adults. Addition of additional intrathecal (spinal) antitoxin does not add any benefit compared to treatment with intramuscular antitoxin alone.