Professor Tom Williams
Honorary Visiting Research Fellow in Tropical Medicine
Tom is Professor of Haemoglobinopathy Research at Imperial College, London. Tom has worked in Kilifi since May 2000, where he now directs a programme of human genetic research with a focus on polymorphisms of the red blood cell.
He obtained his medical degree at Westminster Medical School in the University of London in 1985 and subsequently trained in Paediatrics and Tropical Medicine at a range of London hospitals including Westminster Children's Hospital, University College, the Hospital for Tropical Diseases and Imperial College. He obtained his PhD on the genetics of malaria resistance in children, from the University of London in 1999.
He has published extensively on the burden and clinical consequences of red cell genetic disorders and their relationship with malaria protection, questions which he studies using both laboratory-based and epidemiological approaches.
Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial
Taylor WR. et al, (2023), The Lancet Infectious Diseases, 23, 471 - 483
Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response
Kapulu MC. et al, (2022), BMC Infectious Diseases, 22
Hydroxyurea is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa.
Olupot-Olupot P. et al, (2022), Blood
Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT)
Uyoga S. et al, (2022), The Lancet Child & Adolescent Health, 6, 606 - 613
Substantial misdiagnosis of severe malaria in African children
White NJ. et al, (2022), The Lancet, 400, 807 - 807