Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Alumnus Simon Mendelsohn (2015-2016) co-authored the publication from the study and development of a validated, simple blood-based test that has the potential to serve multiple functions in the fight against TB.

The test, called RISK6, can identify healthy individuals who are at risk of developing tuberculosis (TB) disease, identify people with subclinical or clinical disease and contribute to understanding how well a patient would respond to treatment. And it has now been validated in seven cohorts across two continents.

The researchers also showed that RISK6, which can be applied to capillary blood collected by finger prick, could be developed into a rapid, fingerprick blood-based test device for use at points of care.

This Nature publication paves the way for studies to evaluate and implement the test in community and primary care settings.

Read the publication RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response on the Nature website

Similar stories

Congratulations 2021/22 MSc IHTM

The 2021/22 IHTM cohort gathered at Worcester College to celebrate the culmination of their MSc.

Molecular Detection of Airborne Mycobacterium tuberculosis in South African High Schools

Simon Mendelsohn (cohort 2015-16) co-authored this paper investigating airborne MTB genomic DNA in classrooms as there is evidence of high tuberculosis disease burden among South African adolescents.

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Sandra Adele (cohort 2019-2020) co-authored this paper assessing the benefits of interval extension between BNT162b2 mRNA vaccine doses.

Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol

Simon Mendelsohn (cohort 2015-16) co-authored this systematic review protocol on the current triage and predictive tools and how host tuberculosis transcriptomic biomarkers may be more effective for a correct diagnosis.

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis

Simon Mendelsohn (cohort 2015-16) co-authored this article.

Meeting report: Virtual Global Forum on Tuberculosis Vaccines, 20–22 April 2021

Simon Mendelsohn (cohort 2015-16) co-authored this article on the Global Forum on Tuberculosis (TB) Vaccines and how this year's event focussed on opportunities and challenges for TB vaccine R&D during a pandemic.