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Blog by Piero Olliaro, Josephine Bourner and Lakshmi Manoharan. The COVID-19 pandemic has highlighted the limits of the current peer-review model, which is collapsing under the number of articles and volume of information, unable to cope with the conflicting needs for speed and quality of information. The peer review process is often slow, opaque, unaccountable and biased; it is now time to focus on tangible improvements, making transparency our top priority. We need a system reset, not tinkering in the margin.