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Curators of biological databases transfer knowledge from scientific publications, a laborious and expensive manual process. Machine learning algorithms can reduce the workload of curators by filtering relevant biomedical literature, though their widespread adoption will depend on the availability of intuitive tools that can be configured for a variety of tasks. We propose a new method for supporting curators by means of document categorization, and describe the architecture of a curator-oriented tool implementing this method using techniques that require no computational linguistic or programming expertise. To demonstrate the feasibility of this approach, we prototyped an application of this method to support a real curation task: identifying PubMed abstracts that contain allergen cross-reactivity information. We tested the performance of two different classifier algorithms (CART and ANN), applied to both composite and single-word features, using several feature scoring functions. Both classifiers exceeded our performance targets, the ANN classifier yielding the best results. These results show that the method we propose can deliver the level of performance needed to assist database curation.

Type

Journal article

Journal

Genome informatics. International Conference on Genome Informatics

Publication Date

01/2005

Volume

16

Pages

32 - 44

Addresses

Institute of Systems Science, National University of Singapore, 25 Heng Mui Keng Terrace, Singapore 119615. olivo@iss.nus.edu.sg

Keywords

Allergens, Feasibility Studies, Computational Biology, Cross Reactions, Protein Structure, Tertiary, Artificial Intelligence, Software, Database Management Systems, Databases, Factual