Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans
Simon Mendelsohn (cohort 2015-16), Pramila Rijal, Sean C. Elias, Samara Rosendo Machado, Julie Xiao, Lisa Schimanski, Victoria O’Dowd, Terry Baker, Emily Barry, Catherine J. Cherry, Jing Jin, Geneviève M. Labbé, Francesca R. Donnellan, Tommy Rampling, Stuart Dowall, Emma Rayner, Stephen Findlay-Wilson, Miles Carroll, Jia Guo, Xiao-Ning Xu, Kuan-Ying A. Huang, Ayato Takada, Gillian Burgess, David McMillan, Andy Popplewell, Daniel J. Lightwood, Simon J. Draper, Alain R. Townsend
Highlights: Therapeutic antibodies for Ebola were isolated from human donors in a vaccine trial The derived antibodies were close to germline in sequence Despite temporal immaturity, their binding kinetics matched established antibodies Vaccine trials can provide a golden opportunity to isolate therapeutic antibodies