Ruan Spies
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SUPERVISORS
Colleges
Ruan Spies
DPhil Student
EDUCATION
- MSc Global Health Science and Epidemiology, University of Oxford 2023
- Medicine, University of Cape Town 2019
PREVIOUS EXPERIENCE
- Community Service Medical Officer (Senior House Officer), New Somerset Hospital, Cape Town, South Africa Jan 2022– Oct 2022
- Intern Medical Doctor (Foundation Year equivalent), Livingstone Hospital Complex, Gqeberha, South Africa Jan 2020 – Dec 2021
THESIS
- How do people get drug-resistant tuberculosis?
People with drug-resistant TB can have acquired their disease in one of two ways: from others through direct transmission or through the selection of drug resistance mutations while receiving first-line TB therapy. Empiric evidence describing the relative contributions of each mechanism to the current burden of drug-resistant in Ho Chi Minh City, Vietnam is lacking.
My project uses whole genome sequencing-derived data to describe TB transmission in Ho Chi Minh City and to infer the relative contributions of transmitted and selected resistance to drug-resistant TB in the city. This may have important implications for public health TB control measures.
Recent publications
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Enhancement and validation of the antibiotic resistance prediction performance of a cloud-based genetics processing platform for Mycobacteria
Westhead J. et al, (2024)
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Spatial Analysis of Drug-Susceptible and Multidrug-Resistant Cases of Tuberculosis, Ho Chi Minh City, Vietnam, 2020-2023.
Spies R. et al, (2024), Emerging infectious diseases, 30, 499 - 509
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Spatial Analysis of Drug-Susceptible and Multidrug-Resistant Cases of Tuberculosis, Ho Chi Minh City, Vietnam, 2020–2023
Spies R. et al, (2024), Emerging Infectious Diseases, 30
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Sputum Color as a Marker for Bacteria in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis.
Spies R. et al, (2023), Annals of the American Thoracic Society, 20, 738 - 748
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The Evolving Spectrum of Kidney Histology in HIV-Positive Patients in South Africa.
Wearne N. et al, (2023), Kidney international reports, 8, 1087 - 1096