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Covid-19 continues to cause huge disruption worldwide. As well as the ongoing immediate health impacts of the pandemic, its economic toll is being felt across the world, particularly in LMICs like Nepal. In addition to the wide-ranging disruption of health services, Covid-19 has shifted research priorities and stalled other essential ongoing research. Despite many problems, Covid-19 has afforded a unique opportunity for a better understanding of health research and methodologies in infectious diseases.