Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

BackgroundIndividuals are reinfected with respiratory syncytial virus (RSV) repeatedly. The nature of reinfection, in relation to RSV genetic and antigenic diversity, is ill defined and has implications for persistence and vaccine control.MethodsWe examined the molecular relatedness of RSV causing primary and repeat infections, by phylogenetic analysis of the attachment (G) gene in 12 infants from a birth cohort in rural Kenya, using nasal wash samples collected during a 16-month period in 2002-2003, which spanned 2 successive epidemics.ResultsSix infants were infected during both epidemics, 4 with RSV-A in the first epidemic followed by RSV-B during the second epidemic and 2 with RSV-A during both epidemics, with no significant G gene sequence variability between samples. Two infants were infected and reinfected with different RSV-A strains during the same epidemic. Possible viral persistence was suspected in the remaining 4 infants, although reinfection with the same variant cannot be excluded.ConclusionsThese are the first data that specifically address strain-specific reinfections in infancy in relation to the primary infecting variant. The data strongly suggest that, following primary infection, some infants lose strain-specific immunity within 7-9 months (between epidemics) and group-specific immunity within 2-4 months (during an epidemic period).

Original publication

DOI

10.1086/498246

Type

Publication Date

01/2006

Volume

193

Pages

59 - 67

Addresses

Division of Immunity and Infection, University of Birmingham, UK. P.D.Scott@warwick.ac.uk

Keywords

Humans, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, Recurrence, Viral Fusion Proteins, Sequence Analysis, DNA, Disease Outbreaks, Phylogeny, Molecular Sequence Data, Infant, Kenya, Female, Male