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Fetal development depends on maternal metabolic energy from mitochondria. We investigated the association of maternal mitochondrial function, represented by mitochondrial DNA copy number (mtDNA-CN) of venous blood, with child birth weight (BW) from 528 randomly selected mothers enrolled in the Supplementation with Multiple Micronutrients Intervention Trial (ISRCTN 34151616). Real-time quantitative PCR of archived blood specimens and regression analysis adjusting for other primary determinants of BW showed that loge mtDNA-CN was inversely associated with BW (β = -204.6, p 

Original publication

DOI

10.1016/j.placenta.2018.08.001

Type

Journal

Placenta

Publication Date

10/2018

Volume

70

Pages

1 - 3

Addresses

Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia.

Keywords

Humans, Birth Weight, DNA, Mitochondrial, Risk Factors, Pregnancy, Infant, Newborn, Infant, Low Birth Weight, Indonesia, Female, Male, DNA Copy Number Variations