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We previously described a novel Plasmodium vivax invasion mechanism into human reticulocytes via the PvRBP2a-CD98 receptor-ligand pair. Using linear epitope mapping, we assessed the PvRBP2a epitopes involved in CD98 binding and recognized by antibodies from patients who were infected. We identified 2 epitope clusters mediating PvRBP2a-CD98 interaction. Cluster B (PvRBP2a431-448, TAALKEKGKLLANLYNKL) was the target of antibody responses in humans infected by P vivax. Peptides from each cluster were able to prevent live parasite invasion of human reticulocytes. These results provide new insights for development of a malaria blood-stage vaccine against P vivax.

Original publication

DOI

10.1093/infdis/jiae111

Type

Journal

The Journal of infectious diseases

Publication Date

09/2024

Volume

230

Pages

e737 - e742

Addresses

A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research, Singapore.

Keywords

Reticulocytes, Humans, Plasmodium vivax, Malaria, Vivax, Membrane Proteins, Protozoan Proteins, Malaria Vaccines, Antibodies, Protozoan, Antigens, Protozoan, Epitopes, Epitope Mapping