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Protective cellular immune responses depend on MHC presentation of pathogen-derived Ag fragments. MHC diversity renders this process sensitive to point mutations coding for altered amino acid sequence of the short target Ag-derived peptides epitopes. Thus, in a given host, a pathogen with an altered epitope sequence will be more likely to escape detection and elimination by the immune system. At a population level, selection by immune pressure will increase the likelihood of polymorphism in important pathogen antigenic epitopes. This mechanism of immune evasion is found in viruses and other pathogens. The detection of polymorphic hot spots in an Ag is often taken as a strong indication of its role in protective immunity. We provide evidence that polymorphisms in the T cell epitopes of a malaria vaccine candidate are unlikely to have been selected by immune pressure in the human host.

Original publication

DOI

10.4049/jimmunol.175.6.3935

Type

Journal article

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Date

09/2005

Volume

175

Pages

3935 - 3939

Addresses

Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand.

Keywords

Animals, Humans, Plasmodium falciparum, Protozoan Proteins, Protozoan Vaccines, Epitopes, T-Lymphocyte, DNA Mutational Analysis, Genotype, Polymorphism, Genetic, Genetic Variation, Selection, Genetic