Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Production of tumor necrosis factor by human macrophages may be induced in vitro by cytoadherent and noncytoadherent strains of Plasmodium falciparum, with an optimal ratio of one to three parasitized erythrocytes per macrophage. Centrifuged and heated crude culture supernatants have the same effect, thus showing the existence of a thermostable soluble factor able to induce this expression. In vitro kinetic experiments have shown that the secretion of tumor necrosis factor appears early, with a maximal peak at 8 h.

Type

Journal

Infection and immunity

Publication Date

01/1990

Volume

58

Pages

214 - 216

Addresses

Unité URA 1344 Centre National de la Recherche Scientifique, Hôpital A. Michallon, Grenoble, France.

Keywords

Erythrocytes, Macrophages, Animals, Plasmodium falciparum, Tumor Necrosis Factor-alpha, Immunity, Cellular