Blood virosphere in febrile Tanzanian children
Frank Kagoro (cohort 2016-17), Samuel Cordeya, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Kristina Keitel, Mylène Docquier, Nicolas Guex, Christian Iseli, Gael Vieille, Philippe Le Mercier, Anne Gleizes, Josephine Samaka, Tarsis Mlaganile, John Masimba, Zamzam Said, Hosiana Temba, Gasser H. Elbanna, Caroline Tapparel, Marie-Celine Zanella , Ioannis Xenarios, Jacques Fellay, Valérie D’Acremont , Laurent Kaiser
Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine screening or available diagnostic tools have limited ability to detect new/unexpected viral variants. An in-depth exploration of the blood virome is therefore necessary to clarify the potential viral origin of fever in children.