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Better research for better health university of oxford and fiocruz partner to improve health research and capacity development globally

Better Research for Better Health: University of Oxford and Fiocruz partner to improve health research and capacity development globally

A new strategic partnership between Fiocruz and The Global Health Network will amplify the impact of Fiocruz’s health research and capacity development initiatives by promoting research capacity building across Portuguese-speaking countries, and enabling research findings from the Zika outbreak to benefit public health worldwide.

Launch of comprehensive public health facility inventory for sub saharan africa

Launch of comprehensive public health facility inventory for sub-Saharan Africa

KWTRP Publication Research

KWTRP has launched a dataset of comprehensive public health facilities from 50 countries in sub- Saharan Africa. This new dataset locates health facilities in relation to the communities they are intended to serve, to help ensure that services are accessible to the right populations and that no one is geographically marginalized from essential services. This is critical for attainment of Sustainable Development Goal 3 on good health and wellbeing.

Antimalarial treatments less effective in severely malnourished children

Antimalarial treatments less effective in severely malnourished children

MORU Publication Research

MORU researchers have found that severe malnutrition is associated with lower exposure to the antimalarial drug lumefantrine in children treated with artemether-lumefantrine, the most common treatment for uncomplicated falciparum malaria. The study, which is the first to specifically address this, calls urgently for further research into optimised dosing regimens for undernourished children.

Rapidly spreading multidrug resistant parasites render frontline malaria drug ineffective in southeast asia

Rapidly spreading multidrug-resistant parasites render frontline malaria drug ineffective in southeast Asia

MORU Publication Research

The findings of two studies, published in The Lancet Infectious Diseases journal, reveal that by 2016–2018 malaria parasites resistant to both artemisinin and its widely used partner drug piperaquine represented more than 80% of the parasites circulating in northeast Thailand and Vietnam, despite having only emerged in western Cambodia in 2008.

New study shows faster way to cure vivax malaria

New study shows faster way to cure vivax malaria

MORU Publication Research

A large clinical trial in Africa and Asia has shown that a 7 day course of high dose primaquine, a drug used to treat P. vivax malaria, is well tolerated and just as effective as the current standard 14 day regimen, according to a study published this week in The Lancet. These findings have important implications for the treatment and elimination of vivax malaria in the Asia Pacific.

Research to investigate the prevalence and causes of rickets in remote nw myanmar

Research to investigate the prevalence and causes of rickets in remote NW Myanmar

MORU Research

Medical Action Myanmar and MOCRU health teams identified a number of children with rickets in remote areas of Myanmar. MOCRU director Frank Smithuis presented the findings of clinical screening to the Minister of Health, alongside treatment results and a plan for a large survey to investigate the prevalence of vitamin D deficiency and its underlying causes.

Bringing science and health research to kenyan schools wins university public engagement with research award

Bringing science and health research to Kenyan schools project wins University Public Engagement with Research Award

Awards & Appointments KWTRP Public Engagement

A project bringing science to Kenyan schools, led by Dr Alun Davis from Kemri Wellcome Trust Research Programme in Kenya and Nuffield Department of Medicine, has won a Project Award in this year’s Vice-Chancellor’s Public Engagement with Research Awards.

Village drama against malaria project wins university public engagement with research award

Village drama against malaria project wins University Public Engagement with Research Award

Awards & Appointments MORU Public Engagement

A project using drama that engages with village communities in Cambodia, led by Professor Phaik Yeong Cheah of the Mahidol Oxford Tropical Medicine Research Unit and Nuffield Department of Medicine, has won a Project award in this year’s Vice-Chancellor’s Public Engagement with Research Awards. The project also won the Vice-Chancellor’s Choice Award for Public Engagement with Research.

Longer follow up needed for malaria treatment in pregnant women

Longer follow-up needed for malaria treatment in pregnant women

MORU Publication Research

New research by Makoto Saito and colleagues at SMRU found that a longer follow-up is required to assess antimalarial drug efficacy in pregnant women. This was found across all drugs assessed in low malaria transmission settings. The report’s authors have called for guidelines specifically for pregnant women and further investigation of optimal follow-up periods in high malaria transmission settings.

Iddo announces new research activities for visceral leishmaniasis

IDDO announces new research activities for visceral leishmaniasis

@Oxford Research

IDDO’s visceral leishmaniasis (VL) collaboration is working on two new projects looking at the treatment of VL. The first is a systematic review of the literature on design and analysis of antileishmanial clinical efficacy studies, and the second is a systematic review of published studies to estimate the baseline risk of serious adverse events and mortality in patients treated with antileishmanial therapies.

Malaria no more debashish das story

Malaria no more UK: Debashish Das' story

@Oxford Research

WWARN Researcher Debashish Das has been involved in clinical research in various settings in Asia and Africa with the Mahidol-Oxford Tropical Medicine Research Unit (MORU) and Médecins Sans Frontières (MSF). His research efforts focus on investigating antimalarial drug resistance and finding treatment solutions for young children

Need for better community engagement during global health emergencies

Need for better community engagement during global health emergencies

@Oxford Conferences & meetings

A workshop held in Dakar, Senegal, 7-18 March, highlighted the need for better community engagement during global health emergencies. An international group of experts in community engagement for health research identified urgent measures to foster involvement of local communities in emergency research, such as the Ebola outbreak in Democratic Republic of Congo.

Bbc news big data can stop malaria outbreaks before they start

BBC News: Big data 'can stop malaria outbreaks before they start'

MORU Publication Research

A ground-breaking study in Bangladesh co-lead by MORU has found that using data from mobile phone networks to track the movement of people across the country can help predict where outbreaks of diseases such as malaria are likely to occur, enabling health authorities to take preventative measures.

New statistical approaches for estimating antimalarial drug efficacy

New statistical approaches for estimating antimalarial drug efficacy

@Oxford Research

WWARN’s Clinical Scientific Group have published research in BMC Medical Research Methodology comparing different statistical approaches for deriving cumulative estimates of drug efficacy from clinical studies. Results indicate that the Cumulative Incidence Function (CIF) approach should be considered as an alternative to the widely used Kaplan-Meier method for calculating efficacy estimates in high transmission areas.

Bangkok premiere of under the mask

Bangkok Premiere of Under the Mask

MORU Public Engagement

MORU, SMRU and FilmAid Foundation invite you to the Bangkok Premiere of Under the Mask on the 17th June. This drama film is based on real testimonies of TB patients. The story follows the lives of our characters as they journey from diagnosis to treatment and help from the SMRU TB team, and explores how each discovers their capacity to overcome the deadly disease and share their knowledge and experience with others. Made in the local language, this film provides an engaging and inspiring tool for raising TB awareness in the community.

Afox in blueprint oxford university staff magazine

AfOx in Blueprint, Oxford University staff magazine

@Oxford Research

Avni Gupta, Communications Officer for AfOx, talks about the work of this university-wide initiative – which brings the University’s long-standing multi-disciplinary engagement with Africa under one platform

The importance of community involvement in tackling ebola

The importance of community involvement in tackling Ebola

@Oxford Public Engagement

In this letter co-signed by Peter Horby and Vicki Marsh, researchers stress the importance of building trusting relationships with communities affected by ebola. As shown in DRC, trust is not a given, which is one of the reasons why community engagement – involving local people in the development of the response from the very start – is so important. In conflict zones this is more difficult than in other emergencies, and yet even more important.

New data access committee begins work on ebola

New Data Access Committee begins work on Ebola

@Oxford Research

IDDO Ebola Data Platform, a pioneering collaboration in Ebola and emerging infections, has today appointed nine members for its first Data Access Committee, overseen and chaired by TDR, the Special Programme for Research and Training in Tropical Diseases, hosted at WHO.

Pint of science thailand 2019 in bangkok and chiang rai

Pint of Science Thailand 2019 in Bangkok and Chiang Rai

MORU Public Engagement

This year, the Pint of Science festival in Thailand is in not one but two cities! Join us in Bangkok at WeLearn on 21st-22nd May, and at Hungry Wolf's in Chiang Rai on 25th May.

Join smru for hand hygiene day

Join SMRU for Hand Hygiene Day

MORU Public Engagement

The 5th May is World Hand Hygiene Day. To raise awareness among staff and the Thai-Myanmar border populations of the importance of hand washing, a simple, proven effective way of infection prevention, the SMRU infection control committee worked with the SMRU clinics and Mae Sot lab staff to create this fantastic video.

Congratulations philip bejon and ric price new fellows of the academy of medical sciences

Congratulations Philip Bejon and Ric Price, new Fellows of the Academy of Medical Sciences

Awards & Appointments General

The Academy of Medical Sciences has elected 50 UK leading figures in biomedical and health sciences to their esteemed Fellowship. Philip Bejon, Director of our Kemri Wellcome Trust Research Programme, and Ric Price, Professor of Global Health at Menzies, Australia and affiliated with OUCRU, are new fellows.

Fever and antibiotic use a theatre initiative in myanmar by mocru

Fever and Antibiotic use, a theatre initiative in Myanmar by MOCRU

MORU Public Engagement

How to change urban Myanmar communities' antibiotics usage habits? Check out 'Fever and Antibiotic Use', a Wellcome-funded community theatre initiative by MOCRU Research Coordinator Dr Myo Maung Maung Swe. Myo uses forum theatre to engage Yangon residents in a lively manner so they can learn when to use antibiotics – or not.

We2019re developing the world2019s first vaccine suitable for humans and livestock

We’re developing the world’s first vaccine suitable for humans and livestock

KWTRP Research

Rift Valley Fever, one of WHO priority diseases, causes abortion and malformation in livestock, as well as occasionally severe symptoms in humans. George Warimwe and colleagues at KWTRP are developing a vaccine suitable for both humans and livestock. This cross-species approach, known as “One Health”, might in the long term accelerate the design and development of vaccines, protecting human health and biodiversity too.

Applications are now open for our short course on mathematical modelling of infectious diseases

Applications are now open for our Short Course on Mathematical Modelling of Infectious Diseases

@Oxford MORU

This 5-day course is aimed at participants with a basic understanding of infectious disease modelling and an aptitude for the R programming language. On completion participants will be able to write and analyse the dynamics of a simple mathematical model and use it to consider cost and intervention scenarios. September 23-27 at St Anne’s College, Oxford

World malaria day seminar 2019 antimalarial treatments for vulnerable groups

World Malaria Day seminar 2019 - Antimalarial treatments for vulnerable groups

@Oxford Event MORU

To mark World Malaria Day on 25 April WWARN’s Dr Makoto Saito and Professor Joel Tarning from the Mahidol Oxford Tropical Medicine Research Unit and Head of WWARN Pharmacometrics presented their work on prevention and treatment of malaria in vulnerable groups at a seminar hosted by the Centre for Tropical Medicine and Global Health

Towards universal health coverage in kenya are we on the right path

Towards Universal Health Coverage in Kenya: Are we on the right path?

KWTRP Research

The attainment of Universal Health Coverage (UHC) is a policy priority at both global and national levels. The Sustainable Development Goals underscore the importance of health and wellbeing for all with three main objectives: equity in access to health services, access to quality health services, and protection from financial risk. In Kenya, although the government has installed UHC as a policy priority, it is still marred in misconstruction and often reduced to health financing. Researchers at KEMRI-Wellcome tracked Kenya’s progress towards UHC between 2003 and 2014 and set out recommendations to support policy makers in designing a body of UHC policy.

Malawi is testing a new malaria vaccine but it2019s still early days

Malawi is testing a new malaria vaccine. But it’s still early days

KWTRP Research

Malaria is a leading cause of death and illness around the world. Over 200 million cases are reported every year, and more than 400 000 people die. More than 90% of cases are reported in sub-Saharan Africa. Scientists have spent decades searching for an effective vaccine. Hence the recent excitement when Malawi’s government announced it had launched a pilot programme for the world’s first malaria vaccine, RTS,S (also known as Mosquirix©), produced by the pharmaceutical company, GSK. It’s the first vaccine to demonstrate significant reduction in malaria in children. The Conversation Africa’s Ina Skosana asked immunologist Faith Osier about RTS,S.

Eliminating malaria in the asia pacific could save 400 000 lives

Eliminating malaria in the Asia-Pacific could save 400,000 lives

MORU Publication Research

Increased funding is needed to eliminate malaria across 22 Asia-Pacific countries and save an estimated 400,000 lives, according to research published in a new collection of studies on Wellcome Open Research.

World malaria day 2019 1

World Malaria Day 2019

@Oxford Public Engagement

The 25 of April is World Malaria Day - a good time to take stock of progress towards dealing with one of the great historical global scourges. Science blog by Kevin Marsh for the University of Oxford.

World malaria day 2019

Faces of malaria

OUCRU Public Engagement

Today April 25 is World Malaria Day. We would like to highlight a malaria photography project by photographer Pearl Gan, in collaboration with OUCRU in Vietnam and EOCRU in Indonesia. Pearl's malaria project aims to bring visibility to the people and their malaria burden through her photographs of them and their environment. She hopes to humanise the faces of malaria and the malaria problem in the Asia-Pacific to audiences unfamiliar with it.

Life app is launching in kenya this week

LIFE, a new smartphone app to train healthworkers to save lives

KWTRP

The Life-saving Instruction for Emergencies (LIFE) is a 3D simulation training app for smartphones that teaches healthcare workers how to manage medical emergencies. LIFE is a scenario-based mobile and virtual reality (VR) gaming platform that teaches healthcare workers to identify and manage medical emergencies using game-like training techniques to reinforce the key steps that need to be performed in order to save lives.

Cherrys story a career launched by first hand experience and a good mentor

Cherry's story: a career launched by first-hand experience and a good mentor

MORU Research

How do you go about building all the skills you need at the start of your research career? Cherry Lim from our MORU unit in Bangkok, Thailand, was lucky to find a good mentor who guided her through this journey, but her own ceaseless curiosity and excitement about research were also important.

Oucru photographer in residence recognised by isntd

OUCRU Photographer in Residence recognised by ISNTD

OUCRU Public Engagement

OUCRU Photographer in Residence Pearl Gan has been awarded the International Society for Neglected Tropical Diseases (ISNTD) Festival Award for her submission to the ISNTD Festival Showcase. Pearl submission included seven photographs, and was recognised for its impact on tropical diseases and its broader development goals.

Tracking resistance results presented at westminster uk houses of parliament

Tracking resistance results presented at Westminster, UK Houses of Parliament

MORU Research

Rob van der Pluijm presented encouraging findings from TRAC II trial analyses of Triple Artemisinin Combination Therapies to the All-Party Parliamentary Group on Malaria & NTDs on March 19th in Westminster at the Houses of Parliament.

Widely used malaria treatment to prevent malaria in pregnant women at risk of failing in areas where drug resistance is rising

Widely used malaria treatment to prevent malaria in pregnant women at risk of failing in areas where drug resistance is rising

@Oxford Research

A global team of researchers, led by a research team at the Liverpool School of Tropical Medicine (LSTM), are calling for a review of drug-based strategies used to prevent malaria infections in pregnant women, in areas where there is widespread resistance to existing antimalarial medicines.

Mapping malaria resistance using the act partner drug molecular surveyor

Mapping malaria resistance using the ACT Partner Drug Molecular Surveyor

@Oxford Research

In an article published in Malaria Journal, members of the WWARN Molecular Scientific and Informatics Group describe the development of WWARN’s ACT Partner Drug Molecular Surveyor. Launched in 2015, this online mapping tool supports the malaria community to track over nearly 20 years the prevalence of the molecular markers that are associated with antimalarial drug resistance.

New project to develop a mda vector control strategy to kill malaria transmitting mosquitoes

New project to develop a MDA vector control strategy to kill malaria-transmitting mosquitoes

KWTRP Research

Global efforts to fight malaria have hit a plateau and new tools are needed to achieve global goals. In this context, a consortium led by the Barcelona Institute for Global Health was awarded $25.3m from Unitaid (unitaid.org) to evaluate mass drug administration of ivermectin to humans and livestock in Tanzania and Mozambique, to kill the mosquitoes that transmit malaria. KWTRP Marta Maia will contribute as lead entomologist to BOHEMIA.

Afox travel grant leads to breakthrough research on zika virus in angola

AfOx Travel Grant leads to breakthrough research on Zika virus in Angola

@Oxford Research

Thanks to an AfOx Travel Grant, Sarah Hill and Nuno Faria from Oxford Department of Zoology travelled to Luanda, Angola, to sequence viruses that cause severe disease. The first genomes of Zika virus detected in patients in Angola were thus sequenced. This method can help reveal the ‘family tree’ of viruses and better understand how viruses spread across the world. The researchers have now started to sequence additional viral genomes, from dengue and yellow fever, for similar studies on these viruses.

Paul sondo from nanoro burkina faso recounts the highlights from his crdf fellowship at wwarn

Paul Sondo from Nanoro, Burkina Faso, recounts the highlights from his CRDF Fellowship at WWARN

@Oxford Research

Paul Sondo, molecular parasitologist from the Clinical Research Unit of Nanora in Burkina Faso, spent the last 12 months with WWARN as a recipient of the Clinical Research and Development Fellowship. He tells us about his experience as a CRDF Fellow and how it is starting to impact on his clinical research back at the Clinical Research Unit of Nanora.

Mass drug administration against malaria seen effective

Mass drug administration against malaria seen effective

MORU Research

Lorenz Von Seidlein tells SciDev.Net that mass drug administration as “presumptive treatment” to clear the parasite reservoir was carried out in eight villages spread across Cambodia, Lao PDR, Myanmar and Vietnam. By the third month, the prevalence of P. falciparum had decreased by 92 % in those villages. Over the subsequent nine months, P. falciparum infections returned but stayed well below baseline levels, showing that MDA can stop transmission of falciparum malaria and reduce its prevalence in SE Asia, where resistance to artemisinin has hampered elimination efforts.

Katherine plewes earns canadian grant for kimoru based study

Katherine Plewes earns Canadian grant for KIMORU based study

MORU Research

Working closely with the University of British Columbia (UBC)'s Support Program to Advance Research Capacity (SPARC), MORU Malaria Researcher Dr Katherine Plewes was recently awarded a 3-year, C$971,551 grant for her study on Evaluating the renoprotective effect of acetaminophen in pediatric severe falciparum malaria: A randomized controlled trial.

Iddo launch schistosomiasis and sths platform

IDDO launch Schistosomiasis and STHs platform

@Oxford Research

IDDO launched a new global scientific collaboration dedicated to schistosomiasis and STHs with TDR (the Special Programme for Research and Training in Tropical Diseases). This aims to expand data re-use and collaboration and accelerate better treatment and control of these diseases, which affect more than a billion people globally.

Guide to sepsis management offers comprehensive practical advice for resource limited settings

Guide to sepsis management offers comprehensive, practical advice for resource-limited settings

MORU Publication

On 12 Feb 2019, Professor Arjen Dondorp published a new book: Sepsis Management in Resource-limited Settings. The result of a 3-year project led by MORU and the European Society of Intensive Care Medicine (ESICM), the book was written by critical care physicians from around the globe.

Afox travel grant recipient wins the greenwood africa award 2019

AfOx Travel Grant recipient wins the Greenwood Africa Award 2019

@Oxford Awards & Appointments

Dr Richard Idro is a Senior Lecturer at Makerere University and an Honorary Fellow at Oxford University’s Centre for Tropical Medicine and Global Health. He was been awarded the LSHTM Inaugural Greenwood Africa Award 2019. Dr Idro received an AfOx Travel Grant in 2018 to form a new collaboration between The Ethox Centre at the University of Oxford, KEMRI-Wellcome Trust at Kilifi, Kenya and Makerere University.

Detact study begins will develop two new safe malaria treatments

DeTACT study begins; will develop two new, safe malaria treatments

MORU Research

On 24-25 Jan 2019, investigators met in Bangkok to launch the Developing Triple Artemisinin-based Combination Therapies (DeTACT) Project. Led by MORU and funded by UKaid and the UK Department for International Development (DfID), DeTACT is a large, 14 site trial in 8 African and 5 Asian countries that will study the efficacy, safety and tolerability of two Triple Artemisinin Combination Therapy (TACT) combinations, using combinations of existing antimalarial drugs.

Isaric awarded ps4 5 million to tackle the global threat of epidemic infectious diseases

ISARIC awarded £4.5 million to tackle the global threat of epidemic infectious diseases

@Oxford Research

The International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) has been awarded £4.5 million to accelerate clinical research to prevent illness and deaths from epidemic infectious diseases. ISARIC is a world-wide, grass-roots consortium of clinical research networks, working together on epidemic infections such as pandemic influenza, Ebola, Lassa fever, and plague.

Kemri wellcome gemvi

Kemri Wellcome GeMVI

KWTRP Research

A new project at KEMRI Wellcome aims to bring high throughput pathogen sequencing and predictive models in East Africa. GeMVI plans to engage health authorities and institutes, identify priority questions and fund 20 Research Fellows on locally relevant projects. GeMVI will transfer sequencing technologies, share bioinformatic methods and develop modelling capacity, as well as generate new understanding through predictive modelling and virus sequence data.

Afox partners with ndm oxford to offer summer internships to students from africa

AfOx partners with NDM to offer summer internships to students from Africa.

@Oxford

AfOx, the Africa Oxford Initiative, has partnered with the Nuffield Department of Medicine to offer summer internships to undergraduate and Masters students from Africa. Students will get the opportunity to work in a lab environment and live in Oxford for 8 weeks!

Electronic health records a case study from kenya

Electronic Health Records: a case study from Kenya

@Oxford KWTRP Research

In this background report for the Pathways to Prosperity Commission, Chris Paton and Naomi Muinga describe the implementation of the new OpenMRS-based system called Afya (Swahili for ‘health’) Electronic Health Management System in Machakos County in Kenya. They assess the challenges associated with implementation, and suggest some recommendations for rolling out digital methods to keep clinical records in developing countries.

Ps20 million research hub could help african teens achieve their full potential

£20 million research hub could help African teens achieve their full potential

@Oxford

AfOx joins the University of Oxford to run the UKRI GCRF Accelerating Achievement for Africa’s Adolescents Hub. By 2050 Africa will be home to half a billion teenagers. Despite the incredible opportunity that such a vibrant pool of young potential presents, many of these teens will already be trapped in a cycle of poverty, violence, low education and poor health, by the time they reach adolescence. This new Hub aims to help them achieve their goals and aspirations.

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